The veteran hip-hop producer, whose single features US singer Keri Hilson, last topped the charts in April with Give It To Me, featuring Nelly Furtado.
Kate Nash's Foundations is a non-mover at two, while Fergie ballad Big Girls Don't Cry moves up one place to three.
Britain's Got Talent winner Paul Potts still has the UK's number one album.But his One Chance record had to hold off stiff competition from two debut albums - Amy Macdonald's This Is The Life and Newton Faulkner's Hand Built By Robots - which entered the chart at two and three respectively.
Timbaland's Shock Value has fallen two places to four, while Prince's Ultimate compilation album comes in at six.
Robyn With Kleerup's dance track With Every Heartbeat is a new entry in the singles chart at five.
One of the week's biggest climbers, however, is Hans Zimmer's Spider Pig - taken from the soundtrack of The Simpsons Movie - which has risen 82 places to 24.
This week sees the release of Kate Nash's debut album Made of Bricks and the latest from the Coral, Roots and Echoes.
Source: BBC News
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